Problems with disabled accounts from former employees in your SharePoint User Profile Store ?
This will help you set up Exclusion Filters in the User Profile Synchronization
1) Browse to Central Administration Site > Manage Service Applications > User Profile Service Application.
2) On the Manage Profile Service: User Profile Service Application page, click the Configure Synchronization Connections. This will take you to a page where all the synchronization connections are.
He explains how to set up filters with the userAccountControl attribute from AD user object.